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Abstract
CD8 molecules function as co-receptors on cytotoxic T lymphocytes (CTLs), interacting with a nonpolymorphic region of the major histocompatibility complex (MHC) class I a3 domain on antigen-presenting cells. Analogues were designed from a structural model of the mouse CD8α molecule to identify surfaces involved in CD8 function. Peptides were screened for in vitro biological activity on alloreactive CTLs, and analogue SC4 (p54–59) was found to be inhibitory during both the generation and effector stages. SC4 was also able to significantly prolong skin al log raft survival across a MHC class I barrier. Thus, such CD8αnalogues may have therapeutic potential as immunoregulators of CTL immune responses.Cite this article
Choksi, S., Jameson, B. & Korngold, R. A structure-based approach to designing synthetic CD8α peptides that can inhibit cytotoxic T-lymphocyte responses. Nat Med 4, 309–314 (1998). https://doi.org/10.1038/nm0398-309 