Effects of a urinary factor from women in early pregnancy on HIV-1, SIV and associated disease
Author: ["Yanto Lunardi-Iskandar","Joseph L. Bryant","William A. Blattner","Chia Ling Hung","Louis Flamand","Parkash Gill","Phillipe Hermans","Steven Birken","Robert C. Gallo"]
Publication: Nature Medicine
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Abstract
The effects of clinical grade crude preparations of human chorionic gonadotropin (hCG) on Kaposi's sarcoma, HIV, SIV and hematopoiesis were examined in vitro and in vivo. In contrast to previous studies, we report that the antiviral activity of hCG associated factors is not due to the native hCC heterodimer, including its purified subunits or its major degradation product, the β-core. Using gel permeation chromatography of the clinical grade hCC and urine concentrates from pregnant women, we demonstrate that an as yet unidentified hCG associated factor (HAF) with anti-HIV, anti-SIV, anti-KS and pro-hematopoietic activities elutes as two peaks corresponding to 15–30 kDa and 2–4 kDa.
Cite this article
Lunardi-Iskandar, Y., Bryant, J., Blattner, W. et al. Effects of a urinary factor from women in early pregnancy on HIV-1, SIV and associated disease. Nat Med 4, 428–434 (1998). https://doi.org/10.1038/nm0498-428
