➦ Single-molecule analysis of ligand efficacy in β2AR–G-protein activation
➦ A retinal code for motion along the gravitational and body axes
➦ The metabolic function of cyclin D3–CDK6 kinase in cancer cell survival
➦ Principles of early human development and germ cell program from conserved model systems
➦ Accelerated discovery of two crystal structure types in a complex inorganic phase field
➦ Exosomes facilitate therapeutic targeting of oncogenic KRAS in pancreatic cancer
➦ Layer-dependent ferromagnetism in a van der Waals crystal down to the monolayer limit
➦ The age of the hominin fossils from Jebel Irhoud, Morocco, and the origins of the Middle Stone Age
➦ New fossils from Jebel Irhoud, Morocco and the pan-African origin of Homo sapiens
➦ Microresonator-based solitons for massively parallel coherent optical communications
➦ BAP1 regulates IP3R3-mediated Ca2+ flux to mitochondria suppressing cell transformation
➦ Improved maize reference genome with single-molecule technologies
➦ PTEN counteracts FBXL2 to promote IP3R3- and Ca2+-mediated apoptosis limiting tumour growth
➦ Multilineage communication regulates human liver bud development from pluripotency
➦ Homeostatic circuits selectively gate food cue responses in insular cortex
➦ ERF mutations reveal a balance of ETS factors controlling prostate oncogenesis
➦ Selective depletion of uropathogenic E. coli from the gut by a FimH antagonist
➦ Human fetal dendritic cells promote prenatal T-cell immune suppression through arginase-2
➦ Microglia-dependent synapse loss in type I interferon-mediated lupus
➦ Histone deacetylase 3 prepares brown adipose tissue for acute thermogenic challenge
➦ Rare cell variability and drug-induced reprogramming as a mode of cancer drug resistance
➦ Robust wireless power transfer using a nonlinear parity–time-symmetric circuit
➦ A wet-tolerant adhesive patch inspired by protuberances in suction cups of octopi
➦ Slush-like polar structures in single-crystal relaxors
➦ Host and viral traits predict zoonotic spillover from mammals
➦ Observation of three-component fermions in the topological semimetal molybdenum phosphide
➦ Liquid droplet formation by HP1α suggests a role for phase separation in heterochromatin
➦ Nlrp9b inflammasome restricts rotavirus infection in intestinal epithelial cells
➦ Quantifiable predictive features define epitope-specific T cell receptor repertoires
➦ Trans-kingdom mimicry underlies ribosome customization by a poxvirus kinase
➦ Crystal structure of the potassium-importing KdpFABC membrane complex
➦ Identifying specificity groups in the T cell receptor repertoire
➦ Phase separation drives heterochromatin domain formation
➦ T cells from patients with Parkinson’s disease recognize α-synuclein peptides
➦ Hidden morphological diversity among early tetrapods
➦ Surface tension prevails over solute effect in organic-influenced cloud droplet activation
➦ Microscopy of the interacting Harper–Hofstadter model in the two-body limit
➦ Selective sp3 C–H alkylation via polarity-match-based cross-coupling
➦ Effects of a ketamine metabolite on synaptic NMDAR function
➦ Catalytic allylic oxidation of internal alkenes to a multifunctional chiral building block
➦ Strong constraints on aerosol–cloud interactions from volcanic eruptions
➦ Unique roles for histone H3K9me states in RNAi and heritable silencing of transcription
➦ A massive, dead disk galaxy in the early Universe
➦ Whole-body imaging of lymphovascular niches identifies pre-metastatic roles of midkine
➦ Electron cryo-microscopy structure of the mechanotransduction channel NOMPC
➦ Climate change drives expansion of Antarctic ice-free habitat
➦ Fine-mapping inflammatory bowel disease loci to single-variant resolution
➦ RNase III nucleases from diverse kingdoms serve as antiviral effectors
➦ Recurrent and functional regulatory mutations in breast cancer