➦ Identification of preoptic sleep neurons using retrograde labelling and gene profiling
➦ Architecture of the human interactome defines protein communities and disease networks
➦ Chromatin states define tumour-specific T cell dysfunction and reprogramming
➦ Global translational reprogramming is a fundamental layer of immune regulation in plants
➦ Conversion of adult endothelium to immunocompetent haematopoietic stem cells
➦ Evolutionary enhancement of Zika virus infectivity in Aedes aegypti mosquitoes
➦ PD-1 expression by tumour-associated macrophages inhibits phagocytosis and tumour immunity
➦ Structure of the full-length glucagon class B G-protein-coupled receptor
➦ Cancer progression by reprogrammed BCAA metabolism in myeloid leukaemia
➦ Extreme hydrothermal conditions at an active plate-bounding fault
➦ Isotopic evidence of multiple controls on atmospheric oxidants over climate transitions
➦ Human GLP-1 receptor transmembrane domain structure in complex with allosteric modulators
➦ Experimental characterization of a quantum many-body system via higher-order correlations
➦ Locally noisy autonomous agents improve global human coordination in network experiments
➦ Structure of a pre-catalytic spliceosome
➦ The sunflower genome provides insights into oil metabolism, flowering and Asterid evolution
➦ A neural circuit architecture for angular integration in Drosophila
➦ Zika virus evolution and spread in the Americas
➦ Large conservation gains possible for global biodiversity facets
➦ Genomic epidemiology reveals multiple introductions of Zika virus into the United States
➦ Leaf bacterial diversity mediates plant diversity and ecosystem function relationships
➦ Lymphatic endothelial S1P promotes mitochondrial function and survival in naive T cells
➦ Ensemble cryo-EM elucidates the mechanism of translation fidelity
➦ Applying systems-level spectral imaging and analysis to reveal the organelle interactome
➦ Blocking FSH induces thermogenic adipose tissue and reduces body fat
➦ CPS1 maintains pyrimidine pools and DNA synthesis in KRAS/LKB1-mutant lung cancer cells
➦ Establishment and cryptic transmission of Zika virus in Brazil and the Americas
➦ A cold-atom Fermi–Hubbard antiferromagnet
➦ Cryo-EM structure of the activated GLP-1 receptor in complex with a G protein
➦ Structure of the human multidrug transporter ABCG2
➦ Rapidly star-forming galaxies adjacent to quasars at redshifts exceeding 6
➦ Electric-field control of tri-state phase transformation with a selective dual-ion switch
➦ A Cryptosporidium PI(4)K inhibitor is a drug candidate for cryptosporidiosis
➦ Femtosecond response of polyatomic molecules to ultra-intense hard X-rays
➦ Dynamic corticostriatal activity biases social bonding in monogamous female prairie voles
➦ Crystal structure of the GLP-1 receptor bound to a peptide agonist
➦ Acetyl-CoA synthetase regulates histone acetylation and hippocampal memory
➦ Deletion of a mycobacterial divisome factor collapses single-cell phenotypic heterogeneity
➦ Structure of the Cpf1 endonuclease R-loop complex after target DNA cleavage
➦ RNA phase transitions in repeat expansion disorders
➦ The B-cell receptor controls fitness of MYC-driven lymphoma cells via GSK3β inhibition
➦ Genetic wiring maps of single-cell protein states reveal an off-switch for GPCR signalling
➦ Frequency dependence limits divergent evolution by favouring rare immigrants over residents
➦ The extracellular matrix protein agrin promotes heart regeneration in mice
➦ Dystrophin–glycoprotein complex sequesters Yap to inhibit cardiomyocyte proliferation
➦ Stability and function of regulatory T cells expressing the transcription factor T-bet
➦ A giant planet undergoing extreme-ultraviolet irradiation by its hot massive-star host