➦   Floor-plate-derived netrin-1 is dispensable for commissural axon guidance

➦   Phase-plate cryo-EM structure of a class B GPCR–G-protein complex

➦   Structural insight into allosteric modulation of protease-activated receptor 2

➦   Phylogenetic ctDNA analysis depicts early-stage lung cancer evolution

➦   Cell diversity and network dynamics in photosensitive human brain organoids

➦   Tumour ischaemia by interferon-γ resembles physiological blood vessel regression

➦   Polyglutamine tracts regulate beclin 1-dependent autophagy

➦   The mitochondrial Na+/Ca2+ exchanger is essential for Ca2+ homeostasis and viability

➦   Assembly of functionally integrated human forebrain spheroids

➦   A chromosome conformation capture ordered sequence of the barley genome

➦   The effect of illumination on the formation of metal halide perovskite films

➦   Burgess Shale fossils illustrate the origin of the mandibulate body plan

➦   Discovery of intrinsic ferromagnetism in two-dimensional van der Waals crystals

➦   Human pluripotent stem cells recurrently acquire and expand dominant negative P53 mutations

➦   A 130,000-year-old archaeological site in southern California, USA

➦   Frequency of extreme Sahelian storms tripled since 1982 in satellite observations

➦   Abrasion-set limits on Himalayan gravel flux

➦   Structural basis of CRISPR–SpyCas9 inhibition by an anti-CRISPR protein

➦   Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin

➦   A universal model for solar eruptions

➦   Dominant protection from HLA-linked autoimmunity by antigen-specific regulatory T cells

➦   Experimental evidence that thrust earthquake ruptures might open faults

➦   Whole-genome landscapes of major melanoma subtypes

➦   Thalamic amplification of cortical connectivity sustains attentional control

➦   Core Mediator structure at 3.4 Å extends model of transcription initiation complex

➦   Non-equivalence of Wnt and R-spondin ligands during Lgr5+ intestinal stem-cell self-renewal

➦   Protein–phospholipid interplay revealed with crystals of a calcium pump

➦   Maintenance of persistent activity in a frontal thalamocortical loop

➦   Surrogate Wnt agonists that phenocopy canonical Wnt and β-catenin signalling

➦   FGF-dependent metabolic control of vascular development

➦   Reconciling controversies about the ‘global warming hiatus’

➦   The concurrent emergence and causes of double volcanic hotspot tracks on the Pacific plate

➦   Continental crust formation on early Earth controlled by intrusive magmatism

➦   Remote carboxylation of halogenated aliphatic hydrocarbons with carbon dioxide

➦   A rhodopsin in the brain functions in circadian photoentrainment in Drosophila

➦   Discovery of nitrate–CPK–NLP signalling in central nutrient–growth networks

➦   Intratumoural heterogeneity generated by Notch signalling promotes small-cell lung cancer

➦   Endothelial TLR4 and the microbiome drive cerebral cavernous malformations

➦   TRAF2 and OTUD7B govern a ubiquitin-dependent switch that regulates mTORC2 signalling

➦   Whole-brain serial-section electron microscopy in larval zebrafish

➦   Common genetic variation drives molecular heterogeneity in human iPSCs

➦   A Wnt-producing niche drives proliferative potential and progression in lung adenocarcinoma

➦   Predictive compound accumulation rules yield a broad-spectrum antibiotic

➦   Selectivity determinants of GPCR–G-protein binding

➦   Asia’s glaciers are a regionally important buffer against drought

➦   Preparation and coherent manipulation of pure quantum states of a single molecular ion

➦   Impacts and mitigation of excess diesel-related NOx emissions in 11 major vehicle markets

➦   Multi-phase volcanic resurfacing at Loki Patera on Io

➦   Haematopoietic stem and progenitor cells from human pluripotent stem cells

➦   uORF-mediated translation allows engineered plant disease resistance without fitness costs