➦   Floor-plate-derived netrin-1 is dispensable for commissural axon guidance
➦   Phase-plate cryo-EM structure of a class B GPCR–G-protein complex
➦   Structural insight into allosteric modulation of protease-activated receptor 2
➦   Phylogenetic ctDNA analysis depicts early-stage lung cancer evolution
➦   Cell diversity and network dynamics in photosensitive human brain organoids
➦   Tumour ischaemia by interferon-γ resembles physiological blood vessel regression
➦   Polyglutamine tracts regulate beclin 1-dependent autophagy
➦   The mitochondrial Na+/Ca2+ exchanger is essential for Ca2+ homeostasis and viability
➦   Assembly of functionally integrated human forebrain spheroids
➦   A chromosome conformation capture ordered sequence of the barley genome
➦   The effect of illumination on the formation of metal halide perovskite films
➦   Burgess Shale fossils illustrate the origin of the mandibulate body plan
➦   Discovery of intrinsic ferromagnetism in two-dimensional van der Waals crystals
➦   Human pluripotent stem cells recurrently acquire and expand dominant negative P53 mutations
➦   A 130,000-year-old archaeological site in southern California, USA
➦   Frequency of extreme Sahelian storms tripled since 1982 in satellite observations
➦   Abrasion-set limits on Himalayan gravel flux
➦   Structural basis of CRISPR–SpyCas9 inhibition by an anti-CRISPR protein
➦   Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin
➦   A universal model for solar eruptions
➦   Dominant protection from HLA-linked autoimmunity by antigen-specific regulatory T cells
➦   Experimental evidence that thrust earthquake ruptures might open faults
➦   Whole-genome landscapes of major melanoma subtypes
➦   Thalamic amplification of cortical connectivity sustains attentional control
➦   Core Mediator structure at 3.4 Å extends model of transcription initiation complex
➦   Non-equivalence of Wnt and R-spondin ligands during Lgr5+ intestinal stem-cell self-renewal
➦   Protein–phospholipid interplay revealed with crystals of a calcium pump
➦   Maintenance of persistent activity in a frontal thalamocortical loop
➦   Surrogate Wnt agonists that phenocopy canonical Wnt and β-catenin signalling
➦   FGF-dependent metabolic control of vascular development
➦   Reconciling controversies about the ‘global warming hiatus’
➦   The concurrent emergence and causes of double volcanic hotspot tracks on the Pacific plate
➦   Continental crust formation on early Earth controlled by intrusive magmatism
➦   Remote carboxylation of halogenated aliphatic hydrocarbons with carbon dioxide
➦   A rhodopsin in the brain functions in circadian photoentrainment in Drosophila
➦   Discovery of nitrate–CPK–NLP signalling in central nutrient–growth networks
➦   Intratumoural heterogeneity generated by Notch signalling promotes small-cell lung cancer
➦   Endothelial TLR4 and the microbiome drive cerebral cavernous malformations
➦   TRAF2 and OTUD7B govern a ubiquitin-dependent switch that regulates mTORC2 signalling
➦   Whole-brain serial-section electron microscopy in larval zebrafish
➦   Common genetic variation drives molecular heterogeneity in human iPSCs
➦   A Wnt-producing niche drives proliferative potential and progression in lung adenocarcinoma
➦   Predictive compound accumulation rules yield a broad-spectrum antibiotic
➦   Selectivity determinants of GPCR–G-protein binding
➦   Asia’s glaciers are a regionally important buffer against drought
➦   Preparation and coherent manipulation of pure quantum states of a single molecular ion
➦   Impacts and mitigation of excess diesel-related NOx emissions in 11 major vehicle markets
➦   Multi-phase volcanic resurfacing at Loki Patera on Io
➦   Haematopoietic stem and progenitor cells from human pluripotent stem cells
➦   uORF-mediated translation allows engineered plant disease resistance without fitness costs