➦ Decline in global oceanic oxygen content during the past five decades
➦ Arrays of horizontal carbon nanotubes of controlled chirality grown using designed catalysts
➦ Stable colloids in molten inorganic salts
➦ Early brain development in infants at high risk for autism spectrum disorder
➦ Light-induced structural changes and the site of O=O bond formation in PSII caught by XFEL
➦ Heinrich events triggered by ocean forcing and modulated by isostatic adjustment
➦ Survival of tissue-resident memory T cells requires exogenous lipid uptake and metabolism
➦ Mechanical metamaterials at the theoretical limit of isotropic elastic stiffness
➦ Complement drives glucosylceramide accumulation and tissue inflammation in Gaucher disease
➦ Prefrontal cortex output circuits guide reward seeking through divergent cue encoding
➦ Elucidation of the biosynthesis of the methane catalyst coenzyme F430
➦ Amplified stimulated emission in upconversion nanoparticles for super-resolution nanoscopy
➦ Intragenic DNA methylation prevents spurious transcription initiation
➦ Reconstitution of the tubular endoplasmic reticulum network with purified components
➦ Crystallization of silicon dioxide and compositional evolution of the Earth’s core
➦ Targeting a CAR to the TRAC locus with CRISPR/Cas9 enhances tumour rejection
➦ A simple rule to determine which insolation cycles lead to interglacials
➦ Theory of chaotic orbital variations confirmed by Cretaceous geological evidence
➦ Adipose-derived circulating miRNAs regulate gene expression in other tissues
➦ Seven temperate terrestrial planets around the nearby ultracool dwarf star TRAPPIST-1
➦ TIRR regulates 53BP1 by masking its histone methyl-lysine binding function
➦ Editing and methylation at a single site by functionally interdependent activities
➦ Earth’s first stable continents did not form by subduction
➦ Prophage WO genes recapitulate and enhance Wolbachia-induced cytoplasmic incompatibility
➦ Autophagy maintains the metabolism and function of young and old stem cells
➦ Enzymatic mineralization generates ultrastiff and tough hydrogels with tunable mechanics
➦ An atlas of human long non-coding RNAs with accurate 5′ ends
➦ The molecular architecture of lamins in somatic cells
➦ Mediator structure and rearrangements required for holoenzyme formation
➦ Transcription control by the ENL YEATS domain in acute leukaemia
➦ ENL links histone acetylation to oncogenic gene expression in acute myeloid leukaemia
➦ Cytosolic proteostasis through importing of misfolded proteins into mitochondria
➦ The response of relativistic outflowing gas to the inner accretion disk of a black hole
➦ Supersolid formation in a quantum gas breaking a continuous translational symmetry
➦ Evidence for early life in Earth’s oldest hydrothermal vent precipitates
➦ Rheological separation of the megathrust seismogenic zone and episodic tremor and slip
➦ A stripe phase with supersolid properties in spin–orbit-coupled Bose–Einstein condensates
➦ Paleoproterozoic sterol biosynthesis and the rise of oxygen
➦ Molecular basis of ancestral vertebrate electroreception
➦ Hypersensitive termination of the hypoxic response by a disordered protein switch
➦ Interplay between metabolic identities in the intestinal crypt supports stem cell function
➦ Neanderthal behaviour, diet, and disease inferred from ancient DNA in dental calculus
➦ Aboriginal mitogenomes reveal 50,000 years of regionalism in Australia
➦ MC4R-dependent suppression of appetite by bone-derived lipocalin 2
➦ Class IIa HDAC inhibition reduces breast tumours and metastases through anti-tumour macrophages
➦ KRAB zinc-finger proteins contribute to the evolution of gene regulatory networks
➦ Complex multi-enhancer contacts captured by genome architecture mapping
➦ Observation of discrete time-crystalline order in a disordered dipolar many-body system
➦ Remote site-selective C–H activation directed by a catalytic bifunctional template