Palladium-mediated intracellular chemistry
Author: ["Rahimi M. Yusop","Asier Unciti-Broceta","Emma M. V. Johansson","Rosario M. Sánchez-Martín","Mark Bradley"]
Publication: Nature Chemistry
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Abstract
Many important intracellular biochemical reactions are modulated by transition metals, typically in the form of metalloproteins. The ability to carry out selective transformations inside a cell would allow researchers to manipulate or interrogate innumerable biological processes. Here, we show that palladium nanoparticles trapped within polystyrene microspheres can enter cells and mediate a variety of Pd0-catalysed reactions, such as allylcarbamate cleavage and Suzuki–Miyaura cross-coupling. The work provides the basis for the customization of heterogeneous unnatural catalysts as tools to carry out artificial chemistries within cells. Such in cellulo synthesis has potential for a plethora of applications ranging from cellular labelling to synthesis of modulators or inhibitors of cell function. Palladium nanoparticles trapped within polystyrene beads can enter cells and mediate a variety of Pd0-catalysed reactions, including allylcarbamate cleavage and Suzuki–Miyaura cross-coupling. The methodology presented provides the basis for the customization of heterogeneous unnatural catalysts as tools for carrying out artificial chemistries within cells.
Cite this article
Yusop, R., Unciti-Broceta, A., Johansson, E. et al. Palladium-mediated intracellular chemistry. Nature Chem 3, 239–243 (2011). https://doi.org/10.1038/nchem.981
