➦   Multi-step control of spindle pole body duplication by cyclin-dependent kinase

➦   The APC is dispensable for first meiotic anaphase in Xenopus oocytes

➦   Interaction of WASP/Scar proteins with actin and vertebrate Arp2/3 complex

➦   Separate but linked functions of conventional myosins modulate adhesion and neurite outgrowth

➦   The Hsc70 co-chaperone CHIP targets immature CFTR for proteasomal degradation

➦   A Ran-independent pathway for export of spliced mRNA

➦   The co-chaperone CHIP regulates protein triage decisions mediated by heat-shock proteins

➦   Lack of an endothelial store-operated Ca2+ current impairs agonist-dependent vasorelaxation in TRP4−

➦   Reversible disruption of pericentric heterochromatin and centromere function by inhibiting deacetyla

➦   Interphase movements of a DNA chromosome region modulated by VP16 transcriptional activator

➦   Identification of XAF1 as an antagonist of XIAP anti-Caspase activity

➦   Multicolour imaging of post-Golgi sorting and trafficking in live cells

➦   RANTES promotes growth and survival of human first-trimester forebrain astrocytes

➦   Antimycin A mimics a cell-death-inducing Bcl-2 homology domain 3

➦   Translational control by the ER transmembrane kinase/ribonuclease IRE1 under ER stress

➦   Growth-factor-dependent mitogenesis requires two distinct phases of signalling

➦   Identification of small-molecule inhibitors of interaction between the BH3 domain and Bcl-xL

➦   Escape from premature senescence is not sufficient for oncogenic transformation by Ras

➦   Cofilin/ADF is required for cell motility during Drosophila ovary development and oogenesis

➦   Origin of eukaryotic cell nuclei by symbiosis of Archaea in Bacteria is revealed by homology-hit ana

➦   Caenorhabditis elegans auxilin: a J-domain protein essential for clathrin-mediated endocytosis in vi

➦   Ran–GTP coordinates regulation of microtubule nucleation and dynamics during mitotic-spindle assembl

➦   Protein S-nitrosylation: a physiological signal for neuronal nitric oxide

➦   Role of actin polymerization and actin cables in actin-patch movement in Schizosaccharomyces pombe

➦   Ran stimulates spindle assembly by altering microtubule dynamics and the balance of motor activities

➦   Sequential-replenishment mechanism of exocytosis in pancreatic acini

➦   Cytoplasmic localization of p21Cip1/WAF1 by Akt-induced phosphorylation in HER-2/neu-overexpressing

➦   Activation of Arp2/3 complex-mediated actin polymerization by cortactin

➦   A plasma kallikrein-dependent plasminogen cascade required for adipocyte differentiation

➦   c-myc overexpression activates alternative pathways for intracellular proteolysis in lymphoma cells

➦   Bag1–Hsp70 mediates a physiological stress signalling pathway that regulates Raf-1/ERK and cell grow

➦   Influenza virus propagation is impaired by inhibition of the Raf/MEK/ERK signalling cascade

➦   DNA replication control through interaction of E2F–RB and the origin recognition complex

➦   Distinct roles for Gα and Gβγ in regulating spindle position and orientation in Caenorhabditis elega

➦   The cell-cycle regulatory protein Cks1 is required for SCFSkp2-mediated ubiquitinylation of p27

➦   A myosin II mutation uncouples ATPase activity from motility and shortens step size

➦   Rac recruits high-affinity integrin αvβ3 to lamellipodia in endothelial cell migration

➦   ERK phosphorylation drives cytoplasmic accumulation of hnRNP-K and inhibition of mRNA translation

➦   The Arp2/3 complex nucleates actin filament branches from the sides of pre-existing filaments

➦   Phosphorylation of Snapin by PKA modulates its interaction with the SNARE complex

➦   Membrane blebbing during apoptosis results from caspase-mediated activation of ROCK I

➦   Caspase-3-mediated cleavage of ROCK I induces MLC phosphorylation and apoptotic membrane blebbing

➦   Spatial regulation of the exocyst complex by Rho1 GTPase

➦   GTP-dependent segregation of H-ras from lipid rafts is required for biological activity

➦   p190 RhoGAP is the principal Src substrate in brain and regulates axon outgrowth, guidance and fasci

➦   Spinal muscular atrophy disrupts the interaction of ZPR1 with the SMN protein

➦   Skp1 forms multiple protein complexes, including RAVE, a regulator of V-ATPase assembly

➦   A role for the Pkc1p/Mpk1p kinase cascade in the morphogenesis checkpoint

➦   Regulation of death receptor expression and TRAIL/Apo2L-induced apoptosis by NF-κB

➦   Repression of p15INK4b expression by Myc through association with Miz-1