RANTES promotes growth and survival of human first-trimester forebrain astrocytes
Author: ["Moiz Bakhiet","Annelie Tjernlund","Alyaa Mousa","Annica Gad","Staffan Strömblad","William A. Kuziel","Åke Seiger","Jan Andersson"]
Publication: Nature Cell Biology
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Abstract
We have examined the role of α and β chemokines in the promotion of the ontogenetic development of the brain. RANTES was expressed preferentially in human fetal astrocytes in an age-dependent manner. Astrocytes from 5-week-old brains showed high proliferation and reduced survival, whereas 10-week-old astrocytes exhibited opposite effects. These effects were suppressed by anti-RANTES or anti-RANTES receptor antibodies and were enhanced by recombinant RANTES. RANTES induced tyrosine phosphorylation of several cellular proteins and nuclear translocation of STAT-1 in astrocytes. Interferon-γ (IFN-γ) was required for RANTES effects because RANTES induced IFN-γ and only 10-week-old astrocytes expressed the IFN-γ receptor. Blocking of IFN-γ with antibody reversed the effects of RANTES, indicating that cytokine/chemokine networks are critically involved in brain development.
Cite this article
Bakhiet, M., Tjernlund, A., Mousa, A. et al. RANTES promotes growth and survival of human first-trimester forebrain astrocytes. Nat Cell Biol 3, 150–157 (2001). https://doi.org/10.1038/35055057
